Job Description

Bioanalytical Scientist II

Prolific Machines is ushering in a new era of biotechnology with light. Our first-of-its-kind photomolecular platform delivers unprecedented control, precisely guiding cellular behavior when and where it matters most. Unlike existing tools used to control biology, our technology unlocks dynamic control over virtually any cellular function in any cell type. We're enabling partners to unlock robust efficiency, quality, reproducibility, and sustainability advantages across pharmaceuticals and therapeutic proteins. Prolific is supported by leading investors, including Bill Gates's Breakthrough Energy Ventures, Mayfield and SOSV.

Help us create a brighter tomorrow with biology. We're looking for mission-driven, talented, and kind people to join our team.

The Analytical Science team is looking for a talented scientist to collaboratively work with our R&D and Bioprocess teams to purify and characterize broad classes of therapeutic proteins. A successful candidate will bring an outcome-oriented skillset to recombinant protein purification and characterization. You will work collaboratively with our teams to produce and purify diverse proteins from cell culture processes and be comfortable conducting broad characterization of purified species.

Responsibilities

• Develop and optimize protein purification schemes for broad classes of recombinant therapeutic proteins.
• Develop, optimize, and validate assays for protein quality and purity assessments for broad classes of recombinant therapeutic proteins.
• Plan and execute experimentation to understand protein quality through cell line, upstream and downstream process development.
• Execute, summarize and interpret routine and complex therapeutic protein characterizations.
• Qualify and validate assays upholding highly rigorous standards for execution and documentation.
• Routinely operate, maintain, and troubleshoot analytical instrumentation (HPLCs, FPLCs, mass spectrometers).
• Author, review, and implement methods, protocols, validations and standard operating procedures.
• Ensure processes are followed in accordance with these standards.

About You

• Hold a PhD in Analytical Chemistry, Molecular Biology, Biochemistry, Pharmaceutical Sciences, with at least 2+ years of biologics industry experience. Candidates without a PhD but with similar industry experience are encouraged to apply.
• Have illustrated experience in therapeutic protein therapeutic purification across multiple modalities, and are familiar with common characterization approaches (eg. HPLC, SDS, Western Blotting, CE, BLI, LC-MS).
• You have illustrated the ability to develop and execute intact mass, sequence confirmation, and PTM analysis (e.g., glycosylation, disulfide mapping) through mass spectrometry.
• Experience in the development and execution of GLP compliant methods characterizing protein quality attributes across a wide range of therapeutic classes.
• Have hands-on experience operating LC-MS. Experience with Agilent QTOF instrumentation applied to assay protein quality is a plus. Including familiarity with proteomic software.
• Are highly motivated to deliver successful outcomes for internal and external clients.
• Excited to work with internal and external clients to deliver project excellence.
• Have strong communication skills and comfortable teaching and sharing knowledge at multiple levels of technical detail.

$130,000 - $160,000 a year

Diversity: We value diverse people, perspectives, and knowledge. To this end, we aim to foster a sense of belonging that enables everyone to bring their whole, authentic self to work everyday. We are committed to growing a diverse and inclusive team that encompasses all types of people. We believe this can only be achieved by acknowledging the ancestral, historic, and current systemic and communal inequities.

Location: The San Francisco Bay Area (Emeryville, CA)

Benefits: Company-covered medical, dental, and vision insurance for employee and spouse, generous equity package, retirement plan with company contribution, flexible PTO with healthy time off minimums, career coaching and mental health support, and plentiful snacks and free lunch every day!

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